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Laboratory studies suggest specific monoclonal antibody treatments may be less effective for treating cases of COVID-19 caused by variants with certain substitutions or combinations of substitutions in the spike protein.
L452R is present in B.1.526 (Iota), B.1.427 (Epsilon), and B.1.429 (Epsilon) lineages, as well as the B.1.617 (Kappa, Delta) lineages and sub-lineages.
E484K is present in B.1.525 (Eta), P.2 (Zeta), P.1 (Gamma), and B.1.351 (Beta), but only some strains of B.1.526 (Iota) and B.1.1.7 (Alpha).
The combination of K417N, E484K, and N501Y substitutions is present in B.1.351 (Beta).
The combination of K417T, E484K, and N501Y substitutions is present in P.1 (Gamma).
originally posted by: GenerationGap
Can someone tell me how we test to differentiate Common Cold Coronaviruses and COVID-19. Also, can someone tell me how we know for certain these are variants of COVID-19 and not another new Coronavirus weaponized in a lab and "leaked" into the population?
At the beginning of PCR testing if a "COVID-19" PCR test was done on a person with a Common Cold Coronavirus it would come back positive. Has that changed?
originally posted by: thethirdsign
originally posted by: MichiganSwampBuck
Concerning mutated varieties, many studies contradict this idea that they are far more deadly and contagious. The new variants aren't much worse than the original virus and the numbers seem to confirm that, if you go with those reports over the "official" sanctioned ones. The idea that the current vaccines are becoming ineffective hasn't had enough time to prove out, not to mention they are blaming the rise of mutations on those who were never vaccinated, regardless of any natural immunity from previous infections.
.. I have been wondering about mutations myself and from an evolution point of view - an organism will evolve (mutate) to adapt to its environment, the more hostile the environment the more adaptive evolution/mutations required and if the organism cannot evolve/mutate fast enough it dies off or goes extinct, only the fittest will survive. Having said that, which human host do you think will have the most hostile environment for the CoViD virus - Vaccinated or unvaccinated? My guess would be vaccinated. Of course if the unvaccinated catch the virus and the virus remains in his/her system for a loooonnnng time like 6-7 months (eg in people with suppressed immune system like HIV patients), chances to find the mutated virus in his or her system is high as there will be many generations of the virus with a mutation, but will they be more deadly or not is the big question. And if the virus mutates in a patient that has already been vaccinated you can be sure it will be more virulent. I hope I am wrong.
During the COVID-19 pandemic, Shi and other institute scientists formed an expert group to research Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In February 2020, researchers led by Shi Zhengli published an article in Nature titled, "A pneumonia outbreak associated with a new coronavirus of probable bat origin", finding that SARS-CoV-2 is in the same family as SARS, and that it has 96.2% genome overlap with the most closely related known coronavirus, RaTG13. In February 2020, her team published a paper in Cell Research showing that remdesivir and chloroquine inhibited the virus in vitro, and applied for a patent for the drug in China on behalf of the WIV. This caused conflict with an American pharmaceutical firm that had also applied for a patent. Shi co-authored a paper labelling the virus as the first Disease X.
originally posted by: lukey7
Bill Gates loves us...Dr. Fauci is Americas doctor...Cant we just trust them, Dr. Fauci himself said 'just get over it'...Eh, Im a gambler..Ill bet my life (literally) that our leaders and media have integrity and our best interests at heart....anyone who thinks otherwise, to me is a racist...lalalalalalala
Stages of the con In Confessions of a Confidence Man, Edward H. Smith lists the "six definite steps or stages of growth" of a confidence game. He notes that some steps may be omitted.
Foundation work Preparations are made in advance of the game, including the hiring of any assistants required and studying the background knowledge needed for the role.
Approach The victim is approached or contacted.
Build-up The victim is given an opportunity to profit from participating in a scheme. The victim's greed is encouraged, such that their rational judgment of the situation might be impaired.
Pay off or Conviencer The victim receives a small payout as a demonstration of the scheme's purported effectiveness. This may be a real amount of money or faked in some way. In a gambling con, the victim is allowed to win several small bets. In a stock market con, the victim is given fake dividends.
The "hurrah" A sudden manufactured crisis or change of events forces the victim to act or make a decision immediately. This is the point at which the con succeeds or fails. With a financial scam, the con artist may tell the victim that the "window of opportunity" to make a large investment in the scheme is about to suddenly close forever.
The in-and-in A conspirator (in on the con, but assumes the role of an interested bystander) puts an amount of money into the same scheme as the victim, to add an appearance of legitimacy. This can reassure the victim, and give the con man greater control when the deal has been completed.
In addition, some games require a "corroboration" step, particularly those involving a fake, but purportedly "rare item" of "great value". This usually includes the use of an accomplice who plays the part of an uninvolved (initially skeptical) third party, who later confirms the claims made by the con man.